butabarbital will decrease the extent or result of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Effect of coadministering a solid CYP3A4 inducer with fedratinib has not been examined.butabarbital will reduce the level or outcome of glecaprevir/pibrentasvir by impacting hepatic/intestinal